The highest level ever recorded was 194cm during the infamous flood of 1966.
Brugnaro blamed climate change for the "dramatic situation" and called for a speedy completion of a long-delayed project to construct offshore barriers. Water levels on Thursday reached around 130 centimeters (51 inches).
Venice's Mayor, on November 13, prepared to declare the Italian city a disaster zone after the second highest tide ever recorded, flooded its historic basilica and left many of its squares and alleyways deep under water.
"The damage will run into hundreds of millions of euros", Mr Brugnaro warned.
"Tomorrow I will be in the city again, I will meet the local community and we will have another operational meeting in the Prefecture to see the real damage and to give the first solutions".
A tourist takes a photo from the flooded embankment by the Rialto Bridge. Tesserin said climate change and Venice's subsidence problems mean that the city needs to be told immediately if it is likely to work or "we need another plan". Still, he adds, the current combination of high tide and strong winds has resulted in "an exceptional event".
"There's widespread devastation", he said in the famed St. Mark's Square, which bore the brunt of the flooding.
It comes as Venetians woke to sirens indicating that the tide would "remain high" in the coming days, although it was not expected to exceed 130cm (50in) above average sea level, according to the Venetian authorities.
A couple of French tourists said they had "effectively swum" after some of the wooden platforms placed around the city in flood-prone areas overturned.
These floods impact numerous city's building foundations, eroding businesses and homes alike every year. The high water mark reached over 6 feet, the highest level since 1966.
"We feel helpless in the face of nature, but we are also disappointed that either politics or technology has failed", said Claudio Vernier, president of the St Mark's Square Traders' Association. Fortunately, there have not yet been any major injuries or fatalities reported in connection with the flooding.
The city of Venice is under water.
"The storm was so bad it broke the marble flood barrier out front".
One of the most vulnerable parts of the city is the lowest, St. Mark's Square, once described by Napoleon as Europe's drawing room. "It's not just about quantifying the damages, but about the future of this city". The cost will be high.
In Venice, the famous St. Mark's Square was submerged.
The project has been controversial from the beginning, and opinion remains divided over whether the Mose system, when ready to use, will really be able to prevent the city from flooding. Due to cost overruns, construction delays, and corruption within the Italian government, the build-out of all 78 gates essentially halted for five years and missed its target deadline of last year.
The historic church, which dates back to 1092, has been swamped with water following the city's highest tide in 50 years.