Bundesliga champions Bayern Munich have cruised through as Group B winners with five victories from five games, scoring 21 goals - the best total from any side in the group phase.
Through to the last 16 as Group B runners-up.
Last season's beaten finalists Tottenham fought back from 2-0 down to beat Olympiakos 4-2 on Tuesday to go through as group runners-up.
The Blues are now third in their group with 8 points and even a draw could be enough to see them through but for that, they will have to hope that Ajax are able to beat Valencia in their UCL tie. If Napoli were to draw Genk and leave the group in a three-way tie for two positions, the scores of both games could be critical to determining who advances, and in what order.
'It's like a final for us, a must-win match.
Tuesday's matches also see Zenit St Petersburg and Olympique Lyonnais vying to join RB Leipzig in the next round from Group "G" where head-to-head scenarios also come into play. That's always going to be the case, no matter what competition it is", the club's official website quoted Henderson as saying."Every single game is the next biggest game for us and the next biggest challenge. Napoli, like Liverpool, only need a draw to guarantee they escape the group and a win for them won't clinch top spot unless the Reds fail to win. They are guaranteed a Europa League last-32 place at the very least. We won seven games in a row not long ago.
However, Borussia Dortmund will finish second if they earn more points that Inter.
Zenit St Petersburg will progress if they win at Benfica but Lyon can still qualify if they pick up more points than Zenit.
"Just as much as people were saying at the start of the season that we've got all these young boys, this is going to be no problem we don't need any players".
Chelsea would be extremely disappointed if they had to rely on results elsewhere. A draw would also be enough, providing Ajax beat Valencia in the Netherlands.