The oft-injured Jeffery was carted off the field after suffering a non-contact injury in the ankle or Achilles area early in the second quarter.
"I missed my first throw, which should have been an easy throw", Manning said.
"I am waiting on one more test result this afternoon", Pederson said.
He'll get the start in Monday night's game at Philadelphia. "Shoot, I was ready to get in and go". With Agholor and Jeffery injury, the team only has J.J. Arcega-Whiteside and Greg Ward healthy at the position right now.
According to the New York Daily News' Pat Leonard, Giants co-owner John Mara "stormed off past the locker room flanked by the Giants' head of security, a Philadelphia police officer, and a team employee - a virtual media shield".
Jeffery missed two matches against New England and Seattle a month with a foot injury.
Analysis: The Eagles linebackers saw heavy reps here, as did James, who has carved out a solid niche for himself in this phase.
Part of any coach's job, though, is buoying a player's psyche and Pederson obviously wants Wentz feeling good after a rough stretch. Matthews had 4 catches for 33 yards in just two matches. "We are going to work today, and attempt to find something set up here pretty fast because we are back to the field (Wednesday)". The play looked grisly, with the right tackle needing to be helped off and appearing in pain before being ruled out. He addressed the injury situation starting with All-Pro tackle Lane Johnson, who went down after quarterback Carson Wentz was knocked to the ground and fell on Johnson's ankle. Vaitai substituted Johnson when he had been hurt afterwards in the next quarter. Rookie Andre Dilllard, the Eagles' first-round selection, replaced Johnson in this match.
For one last time, Eli Manning was the man under center during a primetime game.
Pederson said running back Miles Sanders, Arcega-Whiteside, along with cornerback Jalen Mills, who abandoned the game Monday with harms (Sanders returned), ought to have the ability to play Sunday.