Burrow ended his career with an NCAA single season-record 60 touchdown passes.
The fifth and final passing TD was the dagger that sent Clemson to its first loss since January 1, 2018.
LSU take on the side from SC in New Orleans to compete for the College Football Playoff National Championship Trophy, with Clemson going into the game as reigning champions after beating Alabama in 2018.
Burrow tied former Hawaii QB Colt Brennan at 58 TD passes with 10 seconds to go before halftime of the national championship game against Clemson when he hit TE Thaddeus Moss for a six-yard touchdown. After ceremonially watching the game from one side during the first half, he made the trek across the field to watch the game from the other side for the next half.
To this point, Ross has 61 catches for 789 yards and eight touchdowns.
While technically the underdog in this matchup against LSU, according to the oddsmakers, Clemson can no longer lay claim to being an underdog.
They'll see a familiar team playing when ACC Atlantic rival Clemson looks to earn their third national championship under Dabo Swinney.
The early lead got to 17-7 after Higgins scored on a 36-yard reverse. Burrow led LSU on a 95-yard drive, taking a hard shot on a long run before finding Thaddeus Moss, son of former National Football League star receiver Randy Moss, standing alone in the end zone.
I've been consistently higher than the market on LSU the entire season until ... For the night, Burrow completed 31 passes on 49 attempts for 463 yards, five touchdowns and no interceptions.
Burrow set records galore in the regular season and College Football Playoff.
Fox News Flash top headlines for January 14 are here.
Chase finished with nine catches for 221 yards. Oh, he's also rushed for 310 yards and four scores as well.
Despite the lack of success on third down, Clemson had a chance at the start of the second half.
By the time LSU was crowned national champion, it was well after midnight on the East coast. Fans from both teams cheered him loudly. Higgins took the handoff, faked a reverse and rolled through several LSU defenders near the goal line to finish in the end zone.
"This season, the LSU hero has done just about whatever he wants".
Both quarterbacks had phenomenal seasons, but in the first half, Burrow reminded everyone why he was the Heisman victor.
LSU would keep Clemson from scoring again in the final quarter and eventually ran out the clock with some big runs from Clyde Edwards-Helaire to claim the national title. LSU later scored to increase their lead on Skalski's Tigers to 35-25.
It is LSU's first time trailing in 25 quarters. But the teams each punted twice on their opening two possessions.
Whether or not the long halftime on top of a almost two-hour first half benefited one team or another isn't the issue. It was LSU's fourth national championship game appearance in the BCS/CFP era, and all four games were played at the Superdome, where LSU is now 3-1 in national title games.
The president also was greeted with loud cheers at that game while waving to the crowd from a box.