At the end of Trump's address, Pelosi tore her copy of the speech in half.
"On the eve of Senate Republicans covering up transgressions and spreading misinformation, I can not in good conscience attend a sham State of the Union when I have seen firsthand the damage Donald J. Trump's rhetoric and policies have inflicted on those I love and those I represent", she said.
As he spoke, Pelosi said, she quickly read ahead through her copy of the speech. She said she viewed Trump's remarks as "a pack of lies" on everything from health care to Medicare and Medicaid.
The two votes came largely along party lines. "That meant nothing to me", she told reporters.
But Pelosi said that she wanted to call awareness to alleged falsehoods contained in the president's address, saying Trump exaggerated or distorted his record on prescription drug prices, health care, and the US economy at large.
Pelosi reportedly slammed the president and his speech during a closed-door meeting with House Democrats on Wednesday morning.
Pelosi's actions play into Trump's assertions that the Democrats are incompetent cry-babies.
Trump emerged confident and ready to press on with his re-election effort on Wednesday after the Democratic-led impeachment drive that he denounced as illegitimate crashed to a halt in the Republican-led Senate. But all of that has been overshadowed by Nancy Pelosi's "rip heard round the world".
Following last year's address, Pelosi's style of applause went viral after The Washington Post referred to it as "withering", "pitying" and "Lucille Bluth-like in its contemptuousness", in reference to the comedic matriarch from "Arrested Development".
"He has shredded the truth in his speech, he shredded the Constitution in his conduct, I shredded his state of his mind address", she said before walking away from the podium, ending the news conference.
Interestingly, there was no mention of the impeachment saga in his speech.