Victory moved United up to fifth in the table, overtaking Sheffield United and Tottenham Hotspur, but remaining three points behind Chelsea, who occupy the final Champions League spot. Perhaps the key quote came at the end of Ed Woodward's opening address, reflecting on what Ole Gunnar Solskjaer has done so far and what he may be able to do in future.
The aggregate score is tied at 1-1 after the away leg.
Apart from these two absentees, Paul Pogba, Marcus Rashford and Lee Grant are also ruled out for this match but the club's official injury report has hinted that both Scott McTominay and Mason Greenwood could be named in the first XI after having missed out in the first leg. "There are good teams in it, we need to get past Brugge and we're looking forward to the game".
Sergio Romero starts in goal instead of David de Gea, as he did in Belgium.
But, Solskjaer might not look to tweak the rest of the team much, given the importance of the game.
Harry Maguire is a certain starter for United at the heart of the defence, while Eric Bailly could return for his second game of the season. The Scotsman returned from injury against Watford at the weekend and should get the nod here ahead of Nemanja Matic, who could use a rest.
"We feel we've added some X-factor quality with Bruno, definitely", Solskjaer said.
United have improved significantly since Bruno Fernandes joined them last month. "The addition of Bruno gives us that little bit of a different flavour".
Fernandes retained his composure despite the long wait and calmly slotted home past Brugge stopper Simon Mignolet.
However, one Twitter user defended Fernandes by saying: "Let's get this straight".
At the same time, United must prepare without Martial, and this is where the signing of Odion Ighalo proves it's value.