250,000 NHS volunteers are needed to help workers in the health sector by delivering medicines, shopping and support "those who are shielded to protect their own health".
The Prime Minister was joined for the daily news conference by Prof Chris Whitty, the chief medical officer, and the government's chief scientific advisor Sir Patrick Vallance.
"If you are well and able to do so safely, I would urge you to sign up today to help the most vulnerable people in our communities as an NHS volunteer responder". In just 24 hours, 405,000 people have responded to the call.
At this hard time for frontline doctors and nurses, sign up here to show your support now to our fearless NHS Heroes.
"But many of those shielding will need our support to do that, and by signing up to be an NHS Volunteer Responder, people who are well can do their bit too".
He said: "Times like this show just how generous the British people are and how much they value our health service - we are blown away by this response and the kindness of our country".
Addressing the nation, the PM said: "We're also in the course of the next couple of days, you'll be hearing more from Rishi Sunak, the Chancellor tomorrow, about what we're doing to help the self employed".
"They will be driving medicines to people, bringing patients home to hospital, and making regular phone calls to check on and support people".
The government has today announced more than 400,000 people have come forward to volunteer for the NHS in the fight against Covid-19.
The patient transport volunteer will chauffeur medically fit and discharged patients back to their home, whereas the NHS transport volunteer will be transporting equipment, medication, and supplies between sites.