The brand new Nationwide Well being Service hospital will exclusively take care of individuals with COVID-19, and sufferers will exclusively be assigned there after their native London hospital reaches its capability.
Prince Charles conducted the opening ceremony by video link from his Scottish home, calling the new facility "a spectacular and nearly unbelievable feat of work".
Prince Charles called the process of converting the space into a hospital "incredible", and thanked everyone involved in the effort from the planners and the builders to the doctors and nurses who will eventually use the facility.
Staff put up some signs at the NHS Nightingale Hospital as the spread of the coronavirus disease (Covid-19) continues, London, Britain, April 3, 2020.
Britain's Prince Charles remotely opened a temporary hospital for COVID-19 patients at London's main exhibition center Friday that can accommodate up to 4,000 people as the number of coronavirus-related deaths reported in the United Kingdom surpassed China's official total.
He noted that the initial agreement with the NHS included a "contribution to some fixed costs" but ExCeL made a decision to cover those.
"It is without doubt a spectacular and nearly unbelievable feat of work in every sense-from its speed of construction as we've heard to its size and the skills of those who have created it".
In the video, he paid tribute to those who have worked tirelessly to create the new hospital, which had been constructed in just nine days.
"But for some it will be a much harder journey".
Members of the army and St John Ambulance have been putting in 15-hour shifts to pull off the transformation from conference centre to 4,000-bed hospital. The owners, U.S. private equity giant Blackstone, said they would not count on the NHS for using its facility.
"Let us also pray, ladies and gentlemen, that it will be required for as short a time, and for as few people as possible", he added.
The hospital is named after Florence Nightingale, who treated British and allied soldiers during the Crimean War of the 1850s and is considered to be the founder of modern nursing.
Health Secretary Matt Hancock, who caught the virus and recently came out of self-isolation, also attended the opening ceremony.
According to the World Health Organization (WHO), the UK's COVID-19 death toll stands at 2,532, while 29,478 have tested positive for coronavirus infections. Apart from her annual Christmas message, she has made only a handful of such broadcasts during her 68-year reign.
Charles said the new hospital was a "spectacular and nearly unbelievable feat of construction" and followed an "extraordinary collaboration".