The aircraft arriving from the eastern city of Lahore was carrying 99 passengers and seven crew members, Abdul Sattar Khokhar said.
Airbus said the plane had logged 47,100 flight hours and 25,860 flights as of Friday.
The pilot was heard transmitting a mayday to the tower shortly before the crash of Flight 8303, which was flying from Lahore to Karachi and carrying many traveling for the Muslim holiday of Eid al-Fitr.
The flight took place after the Civil Aviation Authority (CAA) allowed limited reception of domestic flights just few days back after weeks of lockdown due to the coronavirus pandemic.
A Pakistani International Airline (PIA) plane crashes near Karachi's Model Colony area.
Foreign minister Shah Mahmood Qureshi said the plane crashed into a residential area minutes before it was due to land.
Original reports had said there were 107 passengers and crew on board.
The plane had lost contact with air traffic control just after 14:30 local time (09:30 GMT), an airline spokesman said. Visuals showed plumes of smoke emanating, believed to be from the crash site.
A Pakistani passenger plane with at least 100 people on board crashed in a residential area in the Pakistani city of Karachi on Friday, the country's civil aviation agency said.
The website said that "while on second final approach the crew declared Mayday repeatedly reporting they had lost both engines".
Honking ambulances, and fire brigade vehicles were seen rushing to the scene, where crowds of area residents already gathered.
Hafeez was unable to comment on why the plane crashed into a densely populated area while the pilot still had some semblance of control of the aircraft.
Speaking to the media, PIA CEO Arshad Malik stated that the last message received from the pilots was that there was a technical problem.
Earlier, on Dec 7, 2016, an ATR-42 aircraft of the PIA crashed en route from northern Chitral district to capital Islamabad, claiming lives of all 48 passengers and crewmembers onboard.
Pakistan Prime Minister Imran Khan confirmed that an inquest would be opened into the cause of the crash.
PPP Chairperson Bilawal Bhutto Zardari has expressed shock and deep grief over the PIA crash and called for urgent rescue operations.
The premier promised that an inquiry will immediately be instituted.