Pence also repeated the President's refrain that more testing has led to more cases, however the rise in new cases has outpaced the increase in coronavirus testing.
Public health experts have warned against large public gatherings, such as the ones hosted recently by President Trump, which many attended without wearing masks.
The announcement comes when at least 30 states are seeing a resurgence in the Covid-19 cases, and California, Oklahoma and Texas are seeing new high peaks.
"As you can see, we are facing a serious problem in certain areas", Fauci said. Younger people may think they don't have to worry about Covid-19, but some of them will experience serious complications if infected, and they can pass the virus on to others who are vulnerable to more severe cases, they said.
"What we're missing in this is something we've never faced before: a risk for you is not just isolated to you, because if you get infected, you are part of propagating the dynamic process of a pandemic".
"Our hope and our prayers is that is not the case", Pence replied.
Florida Governor Ron DeSantis on Friday also suspended the sale of alcohol at bars after the state reported a doubling in the number of new COVID-19 cases detected.
National Institute of Allergy and Infectious Diseases Director Anthony Fauci told the Washington Post on Friday that experts are seriously considering "pool testing" patients, which would test groups of people at once, rather that a single test for each individual. One reporter asked Pence, who several times at the briefing encouraged people to listen to guidance from local and state health officials, why the campaign held a rally in Tulsa, Okla., last weekend despite local officials advising against it.