Dr Birx, the White House task force coordinator, said people living in multigenerational households in an area that is experiencing an outbreak should wear masks inside the home to protect the elderly or those with underlying conditions.
She said it was now affecting rural areas as well as big cities.
She added that sticking to health and safety guidelines - such as wearing a mask, maintaining personal hygiene and observing social distancing - was crucial.
Birx's update came after recent data from Johns Hopkins University revealed that more than 4.4 million people have been infected with the coronavirus in the USA and more than 150,000 Americans had died.
"I think the president is spreading disinformation about the virus, and she is his appointee, and so I don't have confidence there, no", said Ms.
And she said her recently travels to several states left her concerned about how the virus is still spreading. "It's into the rural as (well as) urban areas". "We definitely need to take more precautions".
Birx's remarks came as House Speaker Nancy Pelosi told ABC News' Martha Raddatz that she had "no confidence" in Birx. "I have never been called Pollyanna-ish or non-scientific or non-data-driven, and I will stake my 40-year career of those fundamental principles of utilizing data to really implement better programs to save more lives".
In response to a question about whether the federal government should "reset" its approach, Birx said she believed it did so about five or six weeks ago, as cases exploded in the South, by shifting to a local framework.
The Times report repeatedly attacked Birx and contrasted her with Dr. Anthony Fauci, whom the Times praised.
Birx stressed on the importance of wearing masks.
President Donald Trump is set to hold a coronavirus press briefing at 5 p.m.
According to the CDC, the U.S.