With world number one Ashleigh Barty electing not to defend her French title because of the virus, Halep will be the highest ranked player in the tournament and a favourite to win her second French Open title.
Halep, who lost the 2017 and 2018 Rome finals to Elina Svitolina, extended her ideal record in tennis' restart to 10-0.
The 2018 French Open victor will meet Karolina Pliskova, the second seed, who beat fellow Czech Marketa Vondrousova 6-2, 6-4 in the other semifinal.
Said Halep, "It's not the end of the tournament that you wish for, but I felt awesome in the first set and I was very confident that, even if we kept playing, I would have chances to win the match".
No matter how happy the tennis tour has been to get back onto the courts after its five-month lockdown, there is no denying the challenge of the back-to-front schedule that has been forced on the players.. "I love this tournament, and I play well here nearly every year", Halep said.
"But I'm sure that measures will take place there, and we will be safe enough to be okay to play and to be safe".
Halep won the opening set in only 21 minutes as she surrendered just nine points and broke Pliskova's serve in all three of the Czech's service games.
"I knew it was going to be a tough battle".
"Overnight, it started to really not feel good, and so I was thinking about whether I should play at all", Pliskova said.
"It's just another tournament", Halep said.
Simona Halep won her first Rome title and Novak Djokovic claimed his fifth as the top seeds ruled in the Italian capital. She owns a 4-7 lifetime record against the Romanian but has taken their last two matchups, which were both played on hard courts.
Looking ahead, Halep will arrive at Roland Garros with a 14-match winning streak that goes back to the start of Dubai in February.
"I wanted to try, I wanted to fight, but, unfortunately, wasn't able to continue and be competitive".
"I did experience mentally some kind of ups and downs in the first four-five days after that happened". She's now won her last three events and earned her first Rome title after two previous runner-ups.
"I wish you a fast recovery and wish you good luck at the French Open, maybe we will meet again there in the final".