Rafael Nadal, who is seeking a record-extending 13th French Open title and a record-equalling 20th Grand Slam singles crown, was handed a relatively tough path to this year's final at Roland Garros when the draw was made on Thursday (Sept 24).
Cameron Norrie is up against a qualifier while Liam Broady, who will make his French Open debut this year, will be placed in the draw when all of the qualifiers have taken place.
The sixth seed, who was drawn in the same half as top seed Simona Halep, faces a potential fourth-round clash with U.S. Open runner-up Victoria Azarenka.
Due to concerns over traveling during the pandemic, she skipped the U.S. Open, opting to stay in Europe and prepare for Roland Garros, where she won her first Slam in 2018.
Wimbledon was cancelled for the first time since World War II. Nadal also experienced a drastically reduced clay-court build-up, with just two wins from three matches in his only event in Rome.
World number one Novak Djokovic, bidding to win Roland Garros for the second time after his 2016 victory and collect an 18th major, starts against Sweden's Mikael Ymer, ranked 80.
Should world No.2 Halep get through Sara Sorribes Tormo in round one and potentially tricky Swiss lefty Jil Teichman in round two, Halep faces a rematch with Amanda Anisimova.
The victor of that clash could meet 15th seed Marketa Vondrousova in the last 16; the Czech advanced to her first major final in Paris a year ago before falling to Barty.
The British Number 1 has never faced the American player, who hit headlines at Wimbledon past year when she knocked out her idol Venus Williams en route to reaching the fourth round of the Grand Slam aged just 15.
"In the US I think they did a really good job".
The 2020 Roland Garros field is also set to feature Top 10 players Daniil Medvedev, Stefanos Tsitsipas, Zverev, Matteo Berrettini, Gael Monfils and Denis Shapovalov.