The move means the Demon Deacons will dodge a three-week break between games, instead giving Wake Forest off weeks this weekend and on the weekend of October 10.
The ACC championship game is now set to be played December 12 or 19; the Notre Dame-Wake Forest game is the second ACC to move to the December 12 date, following Virginia-Virginia Tech, which was slated to be played this past weekend.
Notre Dame made the announcement Tuesday afternoon after seven positive tests from Monday's testing. The game was originally scheduled to be played Saturday, September 26.
In consultation with the St. Joseph County Department of Health, the Notre Dame Football program has chose to pause all football-related activities until further testing is completed.
ESPN reports "this is now the fourth ACC game impacted because of coronavirus issues". The league opened play with an 11-game season (10 conference plus one non-conference) for each team spread over 13 weeks to allow for flexibility in the schedule, including the conference title game.
South Florida won't play its upcoming game against Florida Atlantic after playing Notre Dame on Saturday.
The hope is daily testing will prevent those who are infected from spreading the virus and cut down on the number of people who end up in quarantine because they were in close contact with someone who tested positive.
"We knew COVID would present challenges throughout the season, and we'll always put student-athlete health and safety at the forefront of our decision making. We look forward to resuming team activities and getting back on the playing field".
Along with Notre Dame-Wake Forest, the ACC previously shifted a Virginia-Virginia Tech game from last Saturday to December 12.
BYU had to postpone its game last week at Army after having players test positive for COVID-19.