As the novel Coronavirus has affected over 31 million people and claimed more than 976,000 lives globally, the healthcare providers are now facing challenge to identify those COVID-19 patients who are at the maximum risk of severe illness or death.
KFL&A Public Health notes that self-isolation is generally for a period of 14 days from the first onset of symptoms, from testing or from diagnosis with COVID-19, whichever is earliest.
A Covid-19 patient's RDW test result "was highly correlated with patient mortality, and the correlation persisted when controlling for other identified risk factors like patient age, some other lab tests and some pre-existing illnesses", said study co-author Dr Jonathan Carlson, of Massachusetts General Hospital (MGH) in Boston. "Because vitamin D deficiency and insufficiency is so widespread in children and adults in the United States and worldwide, especially in the winter months, it is prudent for everyone to take a vitamin D supplement to reduce risk of being infected and having complications from COVID-19".
Further analysis of the study groups revealed that just over half of the patients (55%) received antiviral therapy, and it was more likely to be given to those who presented with fever with shortness of breath and/or septic shock.
"Wearing masks, washing our hands, all those things are barriers to transmissibility, or contagion, but as the virus becomes more contagious it statistically is better at getting around those barriers", said Morens, who is also senior adviser to Anthony S. Fauci, NIAID director.
For the study, the researchers were able to sequence the genomes of 5,085 strains of SARS-CoV-2 in Houston, Texas.
In the Dutch men, the effects were cruel.
His 29-year-old brother succumbed to Covid-19 in an intensive care unit in Rotterdam, after being handled for shock and a fever that soared to 44 levels Celsius (111 levels Fahrenheit).
A study published earlier by British researchers reached much the same conclusion in an examination of 25,000 samples gleaned from Europe.
The men's mutations are rare - occurring in 1 in 10,000 people - and an unlikely explanation for the vast majority of severe Covid-19 cases.
"And at least in theory, such interferon problems could be treated with existing medications and interventions", Casanova said.
Interferons also call in immune cells and alert uninfected cells close by to prepare their defences.
"The rare diseases and the more common forms of the same disease may converge, and we can learn from each other", stated Hoischen.