His first round exit in this year's French Open matched the former world number one's heaviest loss in his Grand Slam career.
Murray has been battling to rediscover form after a lengthy recovery from hip surgery, and is now placed at 111 in the world rankings.
Kyrgios, who has carried out a nasty running battle with six-time major victor Boris Becker, also took exception to Wilander's comments.
Wawrinka defeated Murray 6-1, 6-3, 6-2 in 97 minutes in the match played on Sunday.
"It's going to be hard for me to play the same level as I did before", said Murray.
"Also I've never watched a point of Mats Wilander".
"Is it his right to be out there doing that?
I've been playing, I think, quite well", Murray, who received a wildcard entry to the French Open, said.
The 19-year-old, who has been tipped for big things on the circuit, sports the honour of becoming the first player to win under the new retractable roof over Court Philippe Chatrier.
"I was 26 when I first retired, came back at 28, played until 32 and there was a couple of years I played and should not have taken up the space where there were younger, more motivated players who were better than me".
"Mats is a friend of mine and I respect his opinion greatly, but Andy has every right to take wildcards if they are offered, and tournaments have every right to give them to him if they want to", said Courier on ITV. "I felt well. I have just been trying to be focused". "Hopefully he realizes why he's doing it".
In response, Murray posted a screenshot of Wilander's comments on his Instagram story with a simple caption - "love this". Post that, certain comments from Former Grand Slam victor Mats Wilander caused a major controversy.
"I didn't play any claycourt before this, it's my first one (this year) and it was not easy".
Back at the 2019 Australian Open, it was believed that Murray had retired due to chronic injuries, but his intentions were misconstrued and he has forged ahead with his comeback.
'As it stands, I wouldn't make the ATP Cup team, but my understanding is they are looking to put an ATP event on in Australia the beginning of the year, so that's now what I would be doing. It was rainy and cold, I needed to get used to it, said the 23-year-old Zverev.
"I'm 33 now and I was ranked No. 1 in the world, so it's hard with all the issues that I have had". I'll keep going. Let's see what the next few months hold. It's not the sort of match I would just brush aside and not think about it.
The 31-year-old former world number one complained about the unsafe conditions in the rain and cold as officials tried to make the players wait out a downpour on Court Suzanne Lenglen.
Two-time French Open champion Jim Courier and Nick Kyrgios were among those to defend the Scot, who is the back-to-back and reigning Olympic gold medallist.
The talented Australian remains hopeful of competing at the Australian Open next year despite ongoing restrictions amid the pandemic.