The 94-year-old monarch was joined by her grandson Prince William at the Defence Science and Technology Laboratory at Porton Down near Salisbury, in southern England, and met with scientists battling the virus.
"It's doubling itself again", the queen remarked when discussing the current second wave.
Told it was on the rise and the approach was being evaluated, she added: "Well I suppose it was expected?"
While chatting to Professor Tim Atkins, the Queen managed to perfectly sum up the virus in four words.
The Queen added: "With all these disgusting new things..."
On signing the guest book Thursday at Porton Down, the queen quipped: "Well it proves we've been here, doesn't it?" Her Majesty paired it with a coordinating silk dress and hat by Rachel Trevor Morgan.
A Buckingham Palace spokesperson confirmed that Queen (right) sought expert advice ahead of her visit.
Porton Down has pioneered some of the Covid-19 diagnostic testing and so was able to test everyone prior to them coming into contact with the royals.
The Queen and Prince William.
Someone else added, "Lovely to see the Queen but I think this was really really poor judgement - I don't care your majesty that you can sort out tests for everyone there - the royal family should follow rules just like the rest of us - in fact more so so they set an example". Kensington Palace declared to comment on whether Prince William had been tested.
Face coverings are required by law in certain indoor settings such as on public transport, in shops and places of worship.
The move comes as millions of people in northern England are waiting to find out whether they will be placed under the government's tightest COVID-19 restrictions, which the city of Liverpool already faces.
The Queen also arrived by helicopter separately from the duke, who travelled by vehicle.
Social distancing was maintained during the visit, including between Prince William and his grandmother, who walked two metres apart as they were greeted by staff.
During their trip, the royals met the Porton Down staff and military personnel who were involved in the Novichok clear-up operation, along with scientists helping the response to the COVID-19 pandemic.
It was the monarch's first public engagement outside one of her homes since she attended a Commonwealth Day service at Westminster Abbey on March 9. "Slightly different for me as I'm not out on the front line as I was for Salisbury, but very similar for the organisation".
During lockdown earlier this year, The Queen and Prince Philip shielded from coronavirus at Windsor Castle.
The monarch travelled to Balmoral for her private summer break and then spent a few weeks in Sandringham before returning to Windsor on October 6.