And it's the first spacewalk for both cosmonauts.
Ryzhikov, the station's commander, and Kud-Sverchkov spent almost two hours doing extra leak checks before exiting Russia's Poisk air lock.
Are you anxious about the two astronauts telling each other?
For identification purposes Ryzhikov, callsign EV-1, wears a spacesuit with red stripes and helmet camera 20, while Kud-Sverchkov, EV-2, wears a suit with blue stripes and helmet camera 18.
Sergey Ryzhikov and Sergey Kud-Sverchkov - dubbed Sergey 1 and Sergey 2 by flight controllers - left four Americans and one Japanese inside during their spacewalk, which lasted almost seven hours. NASA's Crumate Kate Rubin will conduct similar tests inside the Russian part of the station.
The live broadcast of the spacecraft, which starts at 9:30 a.m. ET, will be streamed on NASA's website.
The space walk is estimated to take about six hours.
Decommissioning Pirs, which has an airlock and docking ports for cargo and crew vessels, will make way for the long-awaited Russian Multipurpose Laboratory Module, named Nauka - Russian for science.
Two cosmonauts re-entered the International Space Station late Wednesday afternoon EST after a spacewalk that used an airlock on a Russian module for the first time. Like the newly arrived SpaceX crew, the Russian-launched astronauts will remain on board until spring. Pierce will be removed from service, disconnected, and disposed of in the future.
Nauka will start from Kazakhstan next year.
"We welcome any and all modules, especially if there is room for them", Rubins said in October.
On Tuesday, the USA space agency NASA and billionaire Elon Muskin the first joint research flight of the SpaceX company led by.
Zero Gravity Indicators, usually cute toys, let the crew know when they reach space after launch. In the meantime, several spacewalks will be required to move assets from Pirs and Zarya's unit to prepare for Nauka's arrival in April 2021.
Yuri, a young astronaut coordinator Olga, wife of Kudd Svereshkov, accompanied them during their October launch.
On Sunday, NASA astronauts Michael Hopkins, Victor Glover, Shannon Walker, and Soichi Noguchi from the Japan Aerospace Exploration Agency (JAXA) joined ISS Expedition 64.
NASA's Commercial Crew program could expand the astronauts' size in space - meaning more scientific and new types of experiments could take place in the unique microgravity environment.
The seven crew members held a welcoming ceremony on Tuesday.
This is a historic moment for the space station. November 2 marks 20 years of continuous human existence on the space station.
Previously, the space station hosted up to 13 people, but only for a few days when their crews came and went.