Some have called into the question the logic of staging friendlies during the coronavirus pandemic and several games have been called off - such as Norway against Romania - while other countries have had to contend with fielding weakened teams due to positive tests.
Tottenham Hotspur striker Son Heung-min has been confined to his room when not training after six of his South Korea team-mates tested positive for Covid-19 on global duty in Austria, officials said Monday. Last week, Doherty's Ireland team-mate Alan Browne tested positive less than 24 hours after he had played the full 90 minutes of a friendly match with England.
Alongside a picture of himself making use of Tottenham's gym facilities, Mourinho wrote on the worldwide break: "Amazing week of football. After another training session with only six players, it is now time to take care of myself".
"Covid test results after matches been played, randomers running on the pitch while team sessions are taking place and much more".
The Spurs boss has been one of several voices calling for more subs to protect players in a season where fixtures are crowded together, while even the worldwide break has had another game pushed into its midst compared to other years. The Football Association of Wales was made aware of the positive results for Doherty and McClean but said their preparations for Wednesday's game against Finland were not affected.
The 57-year-old had also been unhappy at having to release three of his Tottenham players, including recently fit-again Gareth Bale, to work under Arsenal coach Albert Stuivenberg with Wales.
Speaking earlier this month, Mourinho said: "I don't think any player recharges in the national team".
"It's important that I keep fighting and working as hard as I can to stay in the squad and to stay in the team". I'm only expecting negative things. There have been numerous instances of players testing positive for covid-19 while the global authorities struggle to squeeze in a raft of fixtures in an already overstocked calendar.