"Your reaction to "Folklore" and all the ways in which your imagination honoured that album, I just love you so much and am really, really lucky because of you", she added.
"The last time I received this award it was given to me by the late, great Prince".
Swift beat out Justin Bieber, Post Malone and Roddy Ricch to win the top award, also winning favorite music video and favorite pop/rock female artist.
The Weeknd shocked fans when he walked on stage to accept his best soul/R&B album award at Sunday's American Music Awards with his face bloodied and covered in bandages.
The Starboy hitmaker - who won the Soul/R&B prizes for Favorite Male Artist, Favorite Song for Heartless, and Favorite Album for After Hours - sported a red suit and his head, jaw, and nose completely bandaged during the awards ceremony.
Could this be leading us into The Weeknd's next studio album release?
Kenny G joined the Weeknd for his performance, playing the sax in downtown Los Angeles as the Weeknd walked across a bridge singing "In Your Eyes".
The NFL, Pepsi and Roc Nation announced that the three-time Grammy victor will perform at the 2021 Pepsi Super Bowl Halftime Show on February 7 at Raymond James Stadium in Tampa, Florida.
But she was beaten in the best new artist category by Los Angeles singer Doja Cat, who was also named favorite female soul/R&B artist. She was additionally named Favorite Female Artist (pop/rock) and won Favorite Music Video for her "Cardigan" visuals. Cardi B and Megan Thee Stallion's "WAP" won Favorite Rap/Hip-Hop Song. "I'd like to dedicate this award to him".