Nicola Sturgeon is to open the SNP conference by telling delegates she has "never been so certain" that Scotland will become independent.
Ms Sturgeon said: "If people in Scotland vote for a referendum, there will be a referendum".
"Even away from coronavirus, in fact, then the handling of the Alex Salmon inquiry and her refusal to produce legal documents despite repeated votes in the Scottish Government asking for them".
Opinion polls have shown in subsequent months that a majority of public opinion in Scotland now supports independence, though in a 2014 referendum on the issue the country voted to remain part of the UK.
Boris Johnson, however, has said that while he in power he will not allow another referendum.
Speaking in the Scottish Parliament today (Tuesday November 24), Sturgeon said the Scottish Government is not proposing any changes to the levels now applied to each local authority area, aside from East Lothian.
The current opposition the United Kingdom government holds towards a referendum is unsustainable, said Sturgeon.
Scottish First Minister Nicola Sturgeon has said she wants to hold a second independence referendum as soon as next year, The Times newspaper reported.
His government says there should not be another independence referendum in the near future.
Ms Sturgeon's SNP is expected to perform strongly in elections to the Scottish Parliament in May.
"There's still a lot of uncertainty ahead".
Scottish Liberal Democrat leader Willie Rennie said the government's focus must be exclusively on eliminating COVID-19. I'm a life-long believer and campaigner and advocate for independence, but right now I'm also the first minister of Scotland.
Scottish Labour's Anas Sarwar said it was "insulting" to focus on Scottish independence "in the midst of a global pandemic", adding that the speech proved that Ms Sturgeon "only has one priority - dividing the people of Scotland".