Under the new system, travellers wanting to head into Victoria will need to apply for one of the various permit types, depending on where they've been beforehand.
Interstate locations are to be classified as red, yellow or green, subject to the virus risk in each area.
A red zone means if you have visited this area in the past 14 days you will not be allowed to enter Victoria without an exception or exemption.
An orange zone means that you will be able to apply for a permit and will need to take a coronavirus test within 72 hours after arriving in Victoria, isolating both before and after your test, until you receive a negative result.
Anyone coming from a green zone must also apply for a permit to enter Victoria, but do not need to be tested or isolate.
It's based on red, orange and green "zones" around Australia.
"If we find out what's happened on that floor seven and that's a reason for how it's moved, transmitted, then that might change, but at this point in time it's 14 days because I don't know how that transmission has occurred", she said.
"To do so many tests and have no new cases is a testament to the coronavirus detective work being done by our dedicated team, and the partnership that we have with the Victorian community".
Queensland Premier Annastacia Palaszcuk said on Wednesday that all six cases in the United Kingdom strain Covid-19 cluster were from the same floor. They will be sent back on the next available flight.
Regional New South Wales will become an orange zone tonight, meaning Victorians in the area will be able to return home. Greater Brisbane and Greater Sydney remain red zones.
He said health authorities were considering a similar arrangement for returned travellers from the Greater Brisbane region.
Nearly 200,000 tests have been taken in Victoria since the start of the year.
"When we discovered Greater Brisbane would be locked down, it was a bit disappointing, to be honest - 2021 was supposed to be a new year", Ms Harrington said.
The Premier thanked Victorians who were patiently waiting for public health advice to allow them to return home.
Mr Andrews conceded it was a "deeply inconvenient and challenging time" for Victorians stranded interstate, but insisted he had to follow public health advice.
NSW today recorded three new locally-acquired cases of COVID-19, while Victoria counted its fifth consecutive day with no new local cases.
It brought the state's active case total to 40.
The Department of Health and Human Services also revealed one new infection in returned overseas travellers in hotel quarantine.
The child attended Armadale's Explorers Early Learning Centre, 8km southeast of Melbourne, on January 7.
"While those people affected are not required to undertake a COVID-19 test upon leaving quarantine, they are reminded to continue to monitor for symptoms and get tested if they start to experience even the mildest of symptoms".