The report suggests De Bruyne is likely to be absent for City's Premier League fixtures against West Brom, Sheffield United, and Burnley.
Villa midfielder Douglas Luiz is of interest to City because they have a buy-back clause on the Brazilian that can be activated this summer.
Here's hoping for plenty more fireworks of a different kind during the remaining FA Cup ties this weekend. "You aren't going to get a Ronnie Radford scene where it's like a ploughed field", Duff said, referring to the ex-Hereford United player's FA Cup stunner against Newcastle United on a muddy pitch in 1972.
City have enjoyed an excellent run of form in recent weeks with the victory over Villa extending their run to eight consecutive wins in all competitions, the club now two points behind league leaders Manchester United with a game in hand. A quadruple could be a realistic possibility for them here, or at the very least, a domestic treble.
Earlier this month Wolverhampton Wanderers coach Nuno Espirito Santo was fined £25,000 and warned about his future conduct after saying referee Lee Mason did "not have the quality to whistle a game in the Premier League". Even if we arrive at the game without players, we are going to play the second team, but we don't drop any competition. City eased past Birmingham City with a 3-0 win in the last round. "He felt uncomfortable for two or three days after the positive test - he was exhausted and had the symptoms, but he feels well and we want him to come back". I have had to pay more attention to what they are like as a team.
Verdict: Back the away win at odds of 1/11 and the over 2.5 goals scored at odds of 1/3 (All odds are taken from bet365).