For the second time this week, a strong storm system rolling across the South is bringing a significant dose of snow, sleet, and freezing rain from Texas to New England.

The storm system left behind record-setting cold temperatures with wind-chill warnings extending from the U.S.

In all, at least 16 deaths were reported.

The weather has threatened the nation's COVID-19 vaccination effort.

US President Joe Biden declared an emergency in Texas in a statement Sunday night.

The Weather Channel reports that the storm has already dumped six inches of snowfall on Oklahoma City.

Igee Cummings walks through the snow Monday, Feb. 15, 2021, in Houston.

A frigid blast of winter weather across the US plunged Texas into an unusually icy emergency Monday that knocked out power to nearly 4 million people and shut down airports and icy roads.

Almost 3 million customers remained without power early Wednesday in Texas, Louisiana and MS, more than 200,000 more in four Appalachian states, and almost that many in the Pacific Northwest, according to poweroutage.us, which tracks utility outage reports. The water plant lost power in a blackout Monday.

Texas officials requested 60 generators from the Federal Emergency Management Agency and planned to prioritize hospitals and nursing homes.

Some utilities said they were starting blackouts, while others urged customers to reduce power usage.

ERCOT said it restored power to some 500,000 households Monday afternoon.

"It's worse than a hurricane", Harrell said. He was among the last people to get the shots, which otherwise would not have reached students until March or April.

State health officials said Texas, which was due to receive more than 400,000 additional vaccine doses this week, now does not expect deliveries to occur until at least Wednesday.

The tornado that hit Brunswick County was an EF3 with winds estimated at 160 miles per hour, the weather service said on Twitter.

At least 20 people have died, some while struggling to find warmth inside their homes.

"The sky lit up and there was a lot of pop-pop-popping" and thunder, she said.

Winter weather advisories are in effect for multiple states from coast to coast as a major storm batters the country. A MS man died after losing control of his vehicle, which overtuned on an icy road Monday night near Starkville, Oktibbeha County coroner Michael Hunt said Tuesday.

In North Texas, energy provider Oncor said power outages in the region, previously expected to last just 45 minutes, will be "significantly extended" and told customers to be prepared to be without power for awhile.

Law enforcement reported two men were found dead along Houston-area roadways.

Several cities in the United States saw record lows as Arctic air remained over the central part of the country. Sioux Falls, South Dakota, dropped to minus 26 Fahrenheit.

Air travel in and out of Texas has also been impacted. At midday, more than 2,700 USA flights had been canceled, led by more than 800 at Dallas Fort Worth International Airport and more than 700 at Bush Intercontinental in Houston.

Many school systems have delayed or cancelled face-to-face classes.