None of the vessels before it were affected, but the 15 behind it were detained at anchorages waiting for the Canal to be cleared.
"The container accidentally ran aground after a suspected gust of wind hit it", ship operator Evergreen Marine Corp told AFP. Meteorologists said high winds and a sandstorm had plagued the area on Tuesday, with winds gusting as much as 31mph.
Tugboats are desperately trying to shift the massive vessel as a massive backlog of ships accumulates at the mouth of the Red Sea, and the Great Bitter Lake.
An image posted to Instagram by a user on another waiting cargo ship appeared to showed the Ever Given wedged across the canal as shown in the satellite data. Several tugs have been on scene for several hours working to dislodge the ship.
"All crew are safe and accounted for", said Bernhard Schulte Shipmanagement, which manages the Ever Given.
MarineTraffic showed a map with large clusters of vessels circling at both ends of the canal - in the Mediterranean off Port Said, and in the north of the Red Sea.
He said: "Every day, 50 vessels on average go through that canal, so the closing of the canal means no vessels are transiting north and south".
On a daily basis, about 600,000 barrels of crude or less flow from the Middle East to Europe and the USA via the canal, while volumes from the Atlantic Basin to Asia total about 850,000 barrels a day, according to Anoop Singh, head of East of Suez tanker research at Braemar ACM Shipbroking Pte.
In the opposite direction, it is mostly manufactured goods and grain from Europe and North America headed to the Far East and Asia.
The Ever Given had listed its destination as Rotterdam in the Netherlands prior to getting stuck.
The ship has the capacity to carry 20,000 20-ft shipping containers, according to Reuters news agency.
The lane's water surface width is 313 metres, but the Suez Canal Authority says the navigation channel is between 200 and 210 metres wide.
The canal is a crucial route, mainly used to transport Middle Eastern crude to Europe and the US, as well as shipping fuel oil from the west to the east. In 2015, the government of President Abdel-Fattah el-Sissi completed a major expansion of the canal, allowing it to accommodate the world's largest vessels. Hundreds of thousands have been stuck aboard vessels due to the pandemic.
But Macau said he expects that the Ever Given will be back on its way within a day or two - a timeline that wouldn't noticeably impact global shipping.