Ontario is reporting 3,065 new cases of COVID-19 today and eight more deaths linked to the virus.
According to sources, the order would be in place for four weeks and would halt in-store service for non-essential retailers.
"The COVID-19 situation is at a critical stage and we must act quickly and decisively to stay ahead of these deadly new variants", said Ford.
Officials said the province would also expand booking for COVID-19 vaccine appointments to people aged 50 and over in high-risk neighbourhoods starting Friday.
Solicitor General Sylvia Jones says the stay at home order will be enforced, though did not provide any details as to what that would look like.
Local schools and child care centres remain open, and the Middlesex-London Health Unit has not indicated any intention to close them as other health units around the Toronto region have done. That framework triggered backlash from the small business community for allowing big-box stores to sell non-essential wares while smaller stores were limited to online sales and curbside pickup.
The province will also be organizing mobile vaccination teams and pop-up clinics to administer vaccines in hot spot neighbourhoods in Toronto and Peel Region. During those visits, inspectors have issued over 15,000 orders and over 450 COVID-19 related tickets, and stopped unsafe work related to COVID 19 a total of 24 times. Approximately 5.4 million rapid antigen tests have been sent to over 1,150 workplaces, including 100 essential industry sites, under the Provincial Antigen Screening Program. Vera Etches sent a letter to Dr. David Williams, the province's top doctor on Tuesday, saying the move was "necessary to prevent and mitigate large scale morbidity and mortality and irreparable strain on the health-care system".