While the investigation is still ongoing, Dr. Yaffe said the man had vaccine induced thrombotic thrombocytopenia or VITT at the time of his death - the rare blood clots associated with the AstraZeneca vaccine.
Reminiscent of the first and second round registrations for the AstraZeneca Covid-19 vaccine, the third round opt-in was similarly met with several hiccups within seconds of it going "live" just after noon.
The country received 132,000 doses of the Oxford/Astrazeneca vaccine in late March from Covax, the global initiative to ensure lower-income countries receive jabs, but so far has administered less than 8,000 shots.
Those who received their first dose between March 10 and 19 became eligible to book their second dose on Monday.
"It's a cause of concern for an age group that could potentially be the next most vulnerable, which is the 60-70 age group, this means of all the cohorts vaccinated, the 60-70 bracket will have the lowest level of protection, the longest wait time for a follow-up dose, and be at the greatest risk of ending up in hospital".
The second shots are being moved up by about 2 weeks and being given at the 10 week mark rather than the recommended 12 weeks as the province rushes to use a stockpile of 45,000 doses set to expire in roughly a week. "We have not heard of people dying because they did not get the second dose", he said.
Associate Chief Medical Officer of Health Dr. Barbara Yaffe confirmed the news during the province's bi-weekly update on its COVID-19 response Tuesday.
A spokeswoman for the health minister said many pharmacies and doctors would reach out to patients directly, and asked people to only contact participating pharmacies listed on the province's booking website.
In March, South Sudan received 132,000 doses from Covax but the country's national taskforce on Covid-19 made a decision to return before they expire after discussing the matter with the World Health Organization (WHO).
The case was one of four being investigated for potential correlation between the AstraZeneca vaccine and the formation of blood clots. "I want to reiterate that people who received the dose should feel very confident about their health".
"When it comes to what I understand is your suggestion that we alter the vaccine rollout programme for people in their 60s".
And last week, the Indian government, which is battling a Covid-19 crisis that has seen it suffer shortages of treatment supplies, said it was pooling resources to produce more vaccines of different types.
Meanwhile, the ministry has started rescheduling appointments for the second dose of the AstraZeneca jab, with 12,500 shots already brought forward and another 25,000 due to be arranged in the next few days.