Among Democrats, Clinton, 68, also has a solid double-digit lead in MI opinion polls over rival Bernie Sanders, 74, a United States senator from Vermont.
They resumed their battle on Monday, with Sanders accusing Clinton of distorting his record when she said he opposed the auto bailout credited with rescuing General Motors and Chrysler during the economic crisis. "His commitment [is] to create jobs, reduce inequity and end the disparities between whites and blacks".
"I thought it was at times a little bit disrespectful and there were times where it felt a little bit desperate, both the tone and the nature of the attacks", Clinton spokeswoman Karen Finney said during a Monday appearance on CNN, referring to Sanders's performance.
Sanders has constantly hammered Clinton for that infamous vote, reminding liberal voters on both the campaign trail and during debates.
He also presented one of the weirdest and most tone-deaf responses of the night when talking about race relations.
During the last Republican debate, Trump, Rubio, and Cruz put on a circus as they insulted each other. But his backing from voters has lagged, and he entered Tuesday's contests with just a pair of victories in the Minnesota caucuses and Saturday's Puerto Rico primary.
For Rubio, 44, it's his second win in a campaign that has been dominated by real estate tycoon Trump and Texas Senator Ted Cruz. She is already half-way to winning enough delegates to secure the nomination. He said the move strikes him as "profoundly wrong" and is something "kings and queens demand" of their subjects. Republicans will allocate their delegates during the primary on May the 24th. But they're quickly running out of options and are increasingly weighing long-shot ideas such as a contested convention or rallying around a yet-to-be-determined third-party candidate.
In the Democratic race, Clinton has built a lead of almost 200 pledged delegates over Sanders, and the party's rules awarding delegates proportionally in all states will make it hard for him to catch up because she can keep piling up delegates even in states she loses.