Ms. Wright was 66-years-old.
Beyond performing, Wright operated her own record label, Mrs. B Records, and her own publishing company, Miami Spice. The Grammy Award-winning singer's niece confirmed the news.
"Calling all my #PrayWarriors".
The R&B singer's niece announced her passing on social media but did not reveal a cause of death.
Wright began her decades-long musical career at just 12 years old when she secured her first record deal.
Wright was celebrated not only for her characterful songs but also her voice, which could reach the kind of piercing, ultra-high register the likes of Mariah Carey would later adopt. She had written songs for Michael Jackson, Stevie Wonder, Beyonce and Jennifer Lopez.
The Miami native recorded her debut album at the age of 15, "My First Time Around".
She was nominated twice more for Grammys via her work on British singer Joss Stone's first two albums.
Meanwhile, Betty had her four children Aisha, Patrice, Chaka and Asher, and Patrick, who devastatingly died due to gun violence in 2005. Love ... Lies ... featured rapper Rick Ross and rap producer DJ Khaled.