The blackout comes just days after Iran and the US began indirect negotiations over both countries re-entering the 2015 nuclear deal, possibly imperiling those talks if Iran sees growing pressure on its nuclear program as a reason to push it further.
"We expect that it will be possible to preserve the Joint Comprehensive Plan of Action (JCPOA)", Lavrov said, referring to the 2015 Iran nuclear deal after talks with his Iranian counterpart Mohammad Javad Zarif in Tehran.
On Sunday, an electrical blackout occurred at the facility in Natanz where Iran is operating new centrifuges to refine uranium.
US President Joe Biden has said Tehran must resume full compliance with restrictions on its nuclear activity under the deal before Washington can rejoin the pact.
The mysterious blast at Natanz has sharply heightened tensions between the two powers already engaged in a shadow war on lands and seas across the Middle East, with Iran on Monday vowing to take "revenge".
But Netanyahu repeatedly warned of the threat from the "fanatical regime in Iran" and said Israel will "continue to defend itself against Iran's aggression and terrorism" - while Austin made no mention of Iran in his brief remarks. The attacked damaged an unknown number of centrifuges - sophisticated machines that make uranium usable for nuclear purposes - and has stopped work at the facility for now.
"But the Americans should know that neither sanctions nor acts of sabotage will give them negotiation tools and these acts will only make the situation more hard for them", Zarif told a joint press conference with his visiting Russian counterpart Sergei Lavrov.
The White House said on Monday the United States was not involved in Sunday's attack and had no comment on speculation about the cause of the incident.
Israel did not claim responsibility for the sabotage, but unsourced media reports in the country attributed it to the Israeli security services carrying out a "cyber operation".
The New York Times, quoting unnamed United States and Israeli intelligence officials, also said there had been "an Israeli role" in the attack in which an explosion had "completely destroyed" the power system that fed the plant's "underground centrifuges". "The sabotage won't help talks whose main agenda is to get rid of tough sanctions on Iran". But Iran and the five other world powers still party to it - China, France, Germany, Russia and the United Kingdom - need to find a way for him to lift U.S. sanctions and for Iran to return to the agreed limits on its nuclear programme.
Zarif said Iran has "no problem with returning to implementing JCPOA commitments".
He also blasted the European Union for slapping sanctions on eight Iranian security officials, in response to a crackdown on 2019 street protests, saying that the blacklisting threatens efforts to restore the deal.
"But if this decision has been deliberately taken amid the talks continuing in Vienna to rescue the JCPOA then it is not just unfortunate - this is a mistake that is worse than a crime". Lavrov's remarks come at a time of heightened tensions between Russian Federation and the West over various issues, including Ukraine.
A day earlier, President Hassan Rouhani had officially opened an assembly plant at the site, created to develop centrifuges which can work much faster.
"I can not imagine that they are going simply to say, "We are back to square one", because square one is no longer there", IAEA Director General Rafael Grossi has said.
For now, the agreement remains in limbo with neither Tehran nor Washington backing down from their positions, and each demanding the other make the first move.