"It is possible people will need to get vaccinated against the coronavirus annually", he added.
Pfizer recently announced updated results indicating its vaccine was highly effective up to six months after the second dose, with findings stemming from over 12,000 participants in a late-stage trial.
Residents who received their shots at the state vaccination megasite at the Meadowlands on Friday said they have no problem with a third shot, while others said they figured out that a third dose would be needed.
He said the six months of data shows "extremely, extremely high" protection from COVID-19, noting that protection still "goes down by time".
"A likely scenario is that there will be likely a need for a third dose, somewhere between six and 12 months and then from there, there will be an annual revaccination, but all of that needs to be confirmed", he said, adding that variants will play a "key role".
Bourla also highlighted the importance of reducing the number of potential virus carriers and expressed optimism that vaccines will be an important tool in the battle against the extremely contagious coronavirus variants.
The Pfizer vaccine, developed by the US-based company in partnership with German firm BioNTech, now plays a leading role in American and European vaccination campaigns.
David Kessler, the COVID-19 response chief science officer for President Joe Biden's administration warned that Americans can expect to receive booster shots moving forward to protect against new strains and variants of the virus.
"We are studying the durability of the antibody response", he said. It seems strong but there is some waning of that and no doubt the variants challenge. they make these vaccines work harder.
In the U.S., health officials are already preparing for booster doses to be issued between nine and twelve months after people are fully vaccinated.